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| SCI | New Insights into Limb Formation
Investigators at Burnham Institute for Medical Research and the University of Connecticut Health Center have gained new understanding of the role hyaluronic acid (HA) plays in skeletal growth, chondrocyte maturation and joint formation in developing limbs. Significantly, these discoveries were made using a novel mouse model in which the production of HA is blocked in a tissue-specific manner.
Development, 24-Jul-2009 | 12-Aug-2009
12:25 ET |
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| | —Burnham Institute for Medical Research | View Article |
| SCI | Genome Duplication Responsible for More Plant Species than Previously Thought
Extra genomes appear, on average, to offer no benefit or disadvantage to plants, but still play a key role in the origin of new species, say scientists from Indiana University Bloomington and three other institutions in this week's Proceedings of the National Academy of Sciences.
PNAS | 12-Aug-2009
12:00 ET |
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| | —Indiana University | View Article |
| MED | Mutations in Gene Linked to Ciliopathies
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, have discovered a connection between mutations in the INPP5E gene and ciliopathies. Their findings, which may lead to new therapies for these diseases, will appear in the online edition of Nature Genetics on August 9. (Embargo expired on 09-Aug-2009 at 13:00 ET.)
Nature Genetics, 9-Aug-2009 | 09-Aug-2009
13:00 ET |
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| | —University of California, San Diego Health Sciences | View Article |
| SCI | Unlikely Genetic Suspect Implicated in Common Brain Defect
A genetic search using patients and mouse models has uncovered an unlikely gene involved in Dandy-Walker malformation, a common birth defect which causes mental retardation, motor delays and sometimes autism. This newly discovered function of the gene, which is never expressed in the brain, reveals a novel role for the skull in directing brain development. (Embargo expired on 09-Aug-2009 at 13:00 ET.)
Nature Genetics, Sep-2009 | 09-Aug-2009
13:00 ET |
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| | —University of Chicago Medical Center | View Article |
| SCI | Mary Had a Lot of Lambs: Researchers Identify Way to Accelerate Sheep Breeding
Mary had a little lamb, but only once a year. However, Cornell Sheep Program researchers have discovered an unusual form of a gene that prompts ewes to breed out of season as well as conceive at younger ages and more frequently.
J. of Animal Science, Aug-2009 | 06-Aug-2009
10:15 ET |
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| | —Cornell University | View Article |
| MED | Researchers Decode Structure of an Entire HIV Genome
The structure of an entire HIV genome has been decoded for the first time by researchers at the University of North Carolina at Chapel Hill. The results have widespread implications for understanding the strategies that viruses, like the one that causes AIDS, use to infect humans. (Embargo expired on 05-Aug-2009 at 13:00 ET.)
Nature, 6-Aug-2009 | 05-Aug-2009
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| | —University of North Carolina at Chapel Hill School of Medicine | View Article |
| SCI | On the Move
Rather than sticking to a single DNA script, human brain cells harbor an astonishing genomic variability, according to scientists at the Salk Institute for Biological Studies. The findings, to be published in the Aug. 5, 2009, advance online edition of Nature, could help explain brain development and individuality, as well as lead to a better understanding of neurological disease. (Embargo expired on 05-Aug-2009 at 13:00 ET.)
Nature | 05-Aug-2009
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| | —Salk Institute for Biological Studies | View Article |
| SCI | It’s Not Easy Being Gene Suppressed
Frogs around the world are dying from a fungal pathogen perhaps because they don’t realize they are sick. In a study conducted at the University of Idaho, scientists found that the immune system of the study’s frog species failed to respond to the chytrid fungus known as Batrachochytrium dendrobatidis (Bd). In fact, it appears the fungal infection may actually suppress its victim’s immune system.
PLoS ONE | 05-Aug-2009
12:00 ET |
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| | —University of Idaho | View Article |
| MED | Developing Gene Therapy to Fight Blindness
An international team of scientists and clinicians from the United States and Saudi Arabia are working to develop gene therapy for treating a rare, hereditary retinal disease. The therapy has been shown to restore lost vision in animal models of retinitis pigmentosa (RP). Their work is being funded in part by a $1.5 million grant from the Prince Salman Center for Disability Research in Saudi Arabia, where the recessive gene mutation that leads to the eye disease RP has been found in children from several families. | 30-Jul-2009
23:00 ET |
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| | —University of California, San Diego Health Sciences | View Article |
| MED | Protein Complex Key in Avoiding DNA Repair Mistakes, Cancer
Lymphoma and other cancers may occur when a delicate gene recombination process in antibody-making cells goes awry, according to preliminary studies in mice at the University of Michigan.
Nature Structural and Molecular Biology | 30-Jul-2009
15:15 ET |
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| | —University of Michigan Health System | View Article |
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